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KMID : 0385219950050020122
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Korean Journal of Gerontology
1995 Volume.5 No. 2 p.122 ~ p.128
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Effect of DHA on Neurotransmitters and Their Metabolites in Rabbits
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Choi Jin-Ho
Kim Dong-Woo
Moon Young-Sil
Kim Yong-Sun
Kim Jae-Il
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Abstract
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New Zealand white rabbits were fed commercial basic diets, and administered orally 5.0% and 10% of docosahexaenoic acid(DHA)-rich fish oil including 31.95% of DHA for DHA-5 and DHA-10 groups for 80 days, and experimental Alzheimer’s disease were induced with injection of 1.0% aluminum chloride. Symptom induction period(life-span) of experimental Alzheimer’s disease in rabbits was significantly increased in DHA-10group compared with control group(p<0.05) Acetylcholinesterase activities resulted in a marked increases of about 14.0% and 33.0% in DHA-5 and DHA-10 groups, respectively (p<0.05-0.01). Adminstration effects of DHA-rich fish oil were significantly higher in their metabolites than in neurotransmitters compared with control group. But Monoamine oxidase(MAO)-B activities between control and DHA groups almost did not change. It is believed that chronic administrations of DHA-rich fish oil in these animal model of experimental Alzheimer’s disease induced with 1.0% aluminum chloride in rabbits were more effective in cerebrovascular-type dementia than in Alzheimer’s-type dementia. Therefore, more investigations are also need to explaining the mechanism by which DHA exerts its protective activity on learning and memory impairments of Alzheimer’s disease.
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KEYWORD
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Alzheimer-type dementia, docosahexaenoic acid(DHA), neurotransmitters and their metabolites, acetylcholinesterase(AChE), monoamine oxidase(MAO)-B
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